Virology Trivia Questions

  • ❓ 140+ questions
  • 🗂️ Biology
  • 🎚️ Easy to expert
  • ✨ Free to play

The study of viruses and viral diseases. Play Virology trivia solo to sharpen your knowledge, or challenge a friend head-to-head in Trivia Tango — every question comes with an explanation so you learn as you play. Questions span every level, from easy warm-ups to expert-level stumpers, so there's a real challenge here however much you already know.

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Sample Virology Quiz Questions

A mix of easy, medium and hard — questions run from warm-up to expert, so there's a real challenge at every level. Think you know the answers? Play to find out.

  1. This infectious agent is so small it can only reproduce inside a living host cell, causing diseases from the common cold to COVID-19.

    Difficulty: Easy
    • Virus
    • Bacterium
    • Parasite
    • Fungus
  2. When a host cell is commanded by an invader to produce thousands of copies that then rupture and destroy it, this replication mode is termed this.

    Difficulty: Medium
    • Lytic cycle
    • Binary fission
    • Mitosis
    • Lysogenic cycle
  3. The Picornavirus VPg protein primes RNA synthesis by covalent linkage to uridine residues through this amino acid side chain that becomes phosphodiester-bonded.

    Difficulty: Hard
    • Threonine
    • Histidine
    • Serine
    • Tyrosine
  4. Edward Jenner pioneered this medical procedure in 1796 using cowpox material to protect against smallpox.

    Difficulty: Easy
    • Blood transfusion
    • Chemotherapy
    • Vaccination
    • Surgery
  5. HIV integrates its DNA into the host chromosome using this enzyme, which is now targeted by drugs like raltegravir and dolutegravir.

    Difficulty: Medium
    • Kinase
    • Integrase
    • Protease
    • Ligase
  6. Nodaviruses replicate their bipartite RNA genome entirely in the cytoplasm by forming replication compartments derived from this organelle's outer membrane.

    Difficulty: Hard
    • Mitochondria
    • Golgi apparatus
    • Peroxisomes
    • Endoplasmic reticulum
  7. HIV attacks these immune system components that coordinate the body's defenses, leaving patients vulnerable to opportunistic infections.

    Difficulty: Easy
    • Neurons
    • Red blood cells
    • Platelets
    • T cells
  8. These tiny plant pathogens consist only of naked circular RNA without any protein coat, causing diseases in potatoes and other crops.

    Difficulty: Medium
    • Viroids
    • Plasmids
    • Bacteriophages
    • Prions

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